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Computational and Mathematical Methods in Medicine
Volume 2016, Article ID 2796186, 9 pages
Review Article

Modeling Radiotherapy Induced Normal Tissue Complications: An Overview beyond Phenomenological Models

Laboratory of Medical Physics and Expert Systems, Regina Elena National Cancer Institute, Rome, Italy

Received 14 July 2016; Accepted 23 October 2016

Academic Editor: David A. Winkler

Copyright © 2016 Marco D’Andrea et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


An overview of radiotherapy (RT) induced normal tissue complication probability (NTCP) models is presented. NTCP models based on empirical and mechanistic approaches that describe a specific radiation induced late effect proposed over time for conventional RT are reviewed with particular emphasis on their basic assumptions and related mathematical translation and their weak and strong points.