A Model for Spheroid versus Monolayer Response of SK-N-SH Neuroblastoma Cells to Treatment with 15-Deoxy-PGJ₂

Figure 8

Long-term behavior of SK-N-SH neuroblastoma spheroid, under hypothetical continued treatment, at values of near the critical threshold for the monolayer model. Dashed lines give the behavior for the monolayer model and solid lines give the behavior of the spheroid model. For purposes of comparison, the initial conditions are given by the data set taken from [1], for both the spheroid and monolayer models. Colors represent the five choices of corresponding to the control and four treatment intensities. Note that a small change in creates a substantial response in the monolayer model, while the spheroid dynamics are not much different.