Computational and Mathematical Methods in Medicine / 2016 / Article / Tab 2

Research Article

A Model for Spheroid versus Monolayer Response of SK-N-SH Neuroblastoma Cells to Treatment with 15-Deoxy-PGJ2

Table 2

Summary of treatment parameters for SK-N-SH monolayer culture. Initial conditions have total cells at 100, divided into percents given by , , and for the control (see Table 1).

Cell lineSK-N-SH
SourceKim et al. (2003)
Treatment15-Deoxy- for 24 hrs
Parameter(s),
Computed final total control147.83
Initial conditions for all runs, , ,

Treatment intensity2 μm
Fitted parameter,
Observed at 24 hrs
%  , %  , %  , % dead
57.9%, 25.5%, 16.6%, 8.04%
Computed: %  , %  , %  56.33%, 27.28%, 16.39%
Computed total119.34
Computed mortality8%

Treatment intensity4 μm
Fitted parameter,
Observed at 24 hrs
%  , %  , %  , % dead
51.9%, 26.4%, 21.7%, 10%
Computed: %  , %  , %  51.34%, 26.78%, 21.88%
Computed total109.90
Computed mortality10.09%

Treatment intensity8 μm
Fitted parameter,
Observed at 24 hrs
%  , %  , %  , % dead
48.2%, 23.1%, 28.7%, 17%
Computed: %  , %  , %  47.73%, 27.54%, 24.72%
Computed total97.37
Computed mortality17.03%

Treatment intensity12 μm
Fitted parameter,
Observed at 24 hrs.
%  , %  , %  , % dead
37.6%, 20%, 42.4%, 36%
Computed: %  , %  , %  36.45%, 29.31%, 34.24%
Computed total73.83
Computed mortality26.25%

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