A Model for Spheroid versus Monolayer Response of SK-N-SH Neuroblastoma Cells to Treatment with 15-Deoxy-PGJ₂

Table 2

Summary of treatment parameters for SK-N-SH monolayer culture. Initial conditions have total cells at 100, divided into percents given by , , and for the control (see Table 1).

Cell line	SK-N-SH
Source	Kim et al. (2003)
Treatment	15-Deoxy- for 24 hrs
Parameter(s)	,
Computed final total control	147.83
Initial conditions for all runs	, , ,
Treatment intensity	2 μm
Fitted parameter	,
Observed at 24 hrs; %  , %  , %  , % dead	57.9%, 25.5%, 16.6%, 8.04%
Computed: %  , %  , %	56.33%, 27.28%, 16.39%
Computed total	119.34
Computed mortality	8%
Treatment intensity	4 μm
Fitted parameter	,
Observed at 24 hrs; %  , %  , %  , % dead	51.9%, 26.4%, 21.7%, 10%
Computed: %  , %  , %	51.34%, 26.78%, 21.88%
Computed total	109.90
Computed mortality	10.09%
Treatment intensity	8 μm
Fitted parameter	,
Observed at 24 hrs; %  , %  , %  , % dead	48.2%, 23.1%, 28.7%, 17%
Computed: %  , %  , %	47.73%, 27.54%, 24.72%
Computed total	97.37
Computed mortality	17.03%
Treatment intensity	12 μm
Fitted parameter	,
Observed at 24 hrs.; %  , %  , %  , % dead	37.6%, 20%, 42.4%, 36%
Computed: %  , %  , %	36.45%, 29.31%, 34.24%
Computed total	73.83
Computed mortality	26.25%