Research Article

In Silico Investigation into Cellular Mechanisms of Cardiac Alternans in Myocardial Ischemia

Figure 1

Schematic of the three-state model. S1, S2, and S3 represent the state of SERCA pump in the reaction process. The rate constants are represented by and signs represent the forward or backward direction of reaction. Hydrolysis of MgATP and the release of MgADP/Pi occur in the positive direction during the transformation process. The reaction process is simplified from the E1-E2 model [18, 19].