Investigating Mutations to Reduce Huntingtin Aggregation by Increasing Htt-N-Terminal Stability and Weakening Interactions with PolyQ Domain

<div>Chain B from PDB 3IO6. Orange residues are positions 1–370 and part of the Htt amino terminal region. The red positions 371–387 are the 17 residues of the Htt-N-terminal region implicated in the formation of amyloids (<span class="monospace">MATLEKLMKAFESLKSF</span>). The blue residues are GLN repeats attached to the N-terminal region.</div>

Computational and Mathematical Methods in Medicine

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Figure 1: Investigating Mutations to Reduce Huntingtin Aggregation by Increasing Htt-N-Terminal Stability and Weakening Interactions with PolyQ Domain 

Figure 1 | Investigating Mutations to Reduce Huntingtin Aggregation by Increasing Htt-N-Terminal Stability and Weakening Interactions with PolyQ Domain 