Research Article

Investigating Mutations to Reduce Huntingtin Aggregation by Increasing Htt-N-Terminal Stability and Weakening Interactions with PolyQ Domain

Table 2

Aggregation potentials of top 20 results for Htt-N-term 3-point mutations computed by Zyggregator.

MutantHydrophobicityChargeBeta-sheet propensityAlpha-helical propensityAggregation propensity

Native4.9174.0475.00
M110.4073.8774.39
M212.3173.7175.01
M37.5873.8775.04
M49.5073.8774.87
M511.4173.7175.49
M610.4073.8774.39
M76.6873.8775.52
M811.1373.7175.30
M95.6774.0474.42
M107.5873.8775.04
M1116.6273.5874.24
M1211.8973.7474.27
M1313.8073.5874.89
M1415.7273.5874.72
M1514.8874.1074.67
M169.5073.8774.87
M1710.9973.7474.75
M1810.1574.2674.70
M1912.9073.5875.37
M2012.0674.1075.33