Research Article
Investigating Mutations to Reduce Huntingtin Aggregation by Increasing Htt-N-Terminal Stability and Weakening Interactions with PolyQ Domain
Table 2
Aggregation potentials of top 20 results for Htt-N-term 3-point mutations computed by Zyggregator.
| Mutant | Hydrophobicity | Charge | Beta-sheet propensity | Alpha-helical propensity | Aggregation propensity |
| Native | 4.91 | | 74.04 | 75.00 | | M1 | 10.40 | | 73.87 | 74.39 | | M2 | 12.31 | | 73.71 | 75.01 | | M3 | 7.58 | | 73.87 | 75.04 | | M4 | 9.50 | | 73.87 | 74.87 | | M5 | 11.41 | | 73.71 | 75.49 | | M6 | 10.40 | | 73.87 | 74.39 | | M7 | 6.68 | | 73.87 | 75.52 | | M8 | 11.13 | | 73.71 | 75.30 | | M9 | 5.67 | | 74.04 | 74.42 | | M10 | 7.58 | | 73.87 | 75.04 | | M11 | 16.62 | | 73.58 | 74.24 | | M12 | 11.89 | | 73.74 | 74.27 | | M13 | 13.80 | | 73.58 | 74.89 | | M14 | 15.72 | | 73.58 | 74.72 | | M15 | 14.88 | | 74.10 | 74.67 | | M16 | 9.50 | | 73.87 | 74.87 | | M17 | 10.99 | | 73.74 | 74.75 | | M18 | 10.15 | | 74.26 | 74.70 | | M19 | 12.90 | | 73.58 | 75.37 | | M20 | 12.06 | | 74.10 | 75.33 | |
|
|