TY - JOUR A2 - Pappalardo, Francesco AU - Pang, Liuyong AU - Shen, Lin AU - Zhao, Zhong PY - 2016 DA - 2016/02/22 TI - Mathematical Modelling and Analysis of the Tumor Treatment Regimens with Pulsed Immunotherapy and Chemotherapy SP - 6260474 VL - 2016 AB - To begin with, in this paper, single immunotherapy, single chemotherapy, and mixed treatment are discussed, and sufficient conditions under which tumor cells will be eliminated ultimately are obtained. We analyze the impacts of the least effective concentration and the half-life of the drug on therapeutic results and then find that increasing the least effective concentration or extending the half-life of the drug can achieve better therapeutic effects. In addition, since most types of tumors are resistant to common chemotherapy drugs, we consider the impact of drug resistance on therapeutic results and propose a new mathematical model to explain the cause of the chemotherapeutic failure using single drug. Based on this, in the end, we explore the therapeutic effects of two-drug combination chemotherapy, as well as mixed immunotherapy with combination chemotherapy. Numerical simulations indicate that combination chemotherapy is very effective in controlling tumor growth. In comparison, mixed immunotherapy with combination chemotherapy can achieve a better treatment effect. SN - 1748-670X UR - https://doi.org/10.1155/2016/6260474 DO - 10.1155/2016/6260474 JF - Computational and Mathematical Methods in Medicine PB - Hindawi Publishing Corporation KW - ER -