Spectral Analysis of Dynamic PET Studies: A Review of 20 Years of Method Developments and Applications

Figure 5

Parametric imaging with SA. (a) parametric maps obtained with ESA and SAIF applied to [¹⁸F]FDG PET data. Results refer to the midcalf area in one representative subject, reported in both axial and coronal views. (b) parametric maps obtained with ESA and a modified version of SAIF applied to [¹¹C]SCH442416 brain PET data. Results refer to a representative transaxial slice of a healthy volunteer. map obtained from compartmental quantification is also reported for comparative purposes. (c) Rate of cerebral protein synthesis (rCPS) parametric map obtained with SAIF applied to L[1-¹¹C]Leucine brain PET data. Results refer to a representative transaxial slice of a healthy volunteer. T1-weighted structural MRI and the fraction of blood-derived leucine () are also reported for comparative purposes.

(a) [¹⁸F]FDG PET

(b) [¹¹C]SCH442416 brain PET

(c) L[-¹¹C]Leucine brain PET