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Computational and Mathematical Methods in Medicine
Volume 2016, Article ID 7861653, 17 pages
http://dx.doi.org/10.1155/2016/7861653
Research Article

In Silico Evaluation of the Potential Antiarrhythmic Effect of Epigallocatechin-3-Gallate on Cardiac Channelopathies

1Materials, Natural Substances, Environment and Modeling Laboratory, Multidisciplinary Faculty of Taza, University Sidi Mohamed Ben Abdellah, Fez, Morocco
2Biology, Environment & Health Team, Department of Biology, Faculty of Sciences and Techniques Errachidia, University of Moulay Ismaïl, Meknes, Morocco
3Department of Life and Earth Sciences, Regional Institute of Education and Training Careers, Fez, Morocco
4Team of Nutritional Physiology and Endocrine Pharmacology, Department of Biology, Faculty of Sciences and Techniques Errachidia, University of Moulay Ismaïl, Meknes, Morocco

Received 11 August 2016; Revised 21 September 2016; Accepted 29 September 2016

Academic Editor: Sharon Zlochiver

Copyright © 2016 Maroua Boukhabza et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Ion channels are transmembrane proteins that allow the passage of ions according to the direction of their electrochemical gradients. Mutations in more than 30 genes encoding ion channels have been associated with an increasingly wide range of inherited cardiac arrhythmias. In this line, ion channels become one of the most important molecular targets for several classes of drugs, including antiarrhythmics. Nevertheless, antiarrhythmic drugs are usually accompanied by some serious side effects. Thus, developing new approaches could offer added values to prevent and treat the episodes of arrhythmia. In this sense, green tea catechins seem to be a promising alternative because of the significant effect of Epigallocatechin-3-Gallate (E3G) on the electrocardiographic wave forms of guinea pig hearts. Thus, the aim of this study was to evaluate the benefits-risks balance of E3G consumption in the setting of ion channel mutations linked with aberrant cardiac excitability phenotypes. Two gain-of-function mutations, -p.R222Q and -p.I141V, which are linked with cardiac hyperexcitability phenotypes were studied. Computer simulations of action potentials (APs) show that 30 μM E3G reduces and suppresses AP abnormalities characteristics of these phenotypes. These results suggest that E3G may have a beneficial effect in the setting of cardiac sodium channelopathies displaying a hyperexcitability phenotype.