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Figure 12: Effects of 30 μM E3G on Purkinje cell action potentials for -WT and -p.R222Q conditions (SANNBZ cell model). (a), (b), and (c) Simulated APs (Top of the panels) and the cardiac sodium currents (Bottom of the panels) in WT, heterozygous - p.R222Q, and heterozygous -p.R222Q + 30 μM conditions at 1 Hz cycle length. Arrows: external stimulus. (d) and (e) Strength-duration curves in the SANNBZ cell model for -WT and heterozygous -p.R222Q conditions with or without 30 μM E3G at 2.5 Hz (inset, zoom on the strength-duration curves). (f) Excitation thresholds at 2 ms stimulus duration in the SANNBZ atrial AP or without 30 μM E3G.