Computational and Mathematical Methods in Medicine / 2016 / Article / Fig 13

Research Article

In Silico Evaluation of the Potential Antiarrhythmic Effect of Epigallocatechin-3-Gallate on Cardiac Channelopathies

Figure 13

Effects of 30 μM E3G on Purkinje cell action potentials for -WT and -p.I141V conditions (SANNBZ cell model). (a), (b), and (c) Simulated APs (Top of the panels) and the cardiac sodium currents (Bottom of the panels) in WT, heterozygous -p.I141V, and heterozygous -p.I141V + 30 μM conditions at 1 Hz cycle length. Arrows: external stimulus. (d) and (e) Strength-duration curves in the SANNBZ cell model for -WT and heterozygous -p.I141V conditions with or without 30 μM E3G at 2.5 Hz (inset, zoom on the strength-duration curves). (f) Excitation thresholds at 2 ms stimulus duration in the SANNBZ atrial AP or without 30 μM E3G.

Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.