Computational and Mathematical Methods in Medicine / 2016 / Article / Fig 3

Research Article

In Silico Evaluation of the Potential Antiarrhythmic Effect of Epigallocatechin-3-Gallate on Cardiac Channelopathies

Figure 3

Simulated effects of 30 μM E3G in the human Purkinje model (SANNBZ (Stewart–Aslanidi–Noble–Noble–Boyett–Zhang Purkinje cell model)). (a) Steady state inactivation curves (h) in the presence or absence of E3G. (b) and (c) Inhibitory effect of E3G on the sodium current at −90 mV and −70 mV resting potentials. (d) Inhibitory effect of E3G on the calcium current (20% inhibition). (e) Inhibitory effect of E3G on the current (25% inhibition: dashed line; 50% inhibition: solid line). (f) E3G effect on the Purkinje action potential (intensity of stimulus = 52 μA/μF, duration: 1 ms; inset, zoom of the rapid depolarization phase). For all panels, black lines: without E3G; red lines: 30 μM E3G.

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