In Silico Evaluation of the Potential Antiarrhythmic Effect of Epigallocatechin-3-Gallate on Cardiac Channelopathies
Simulated effects of 30 μM E3G in the human Purkinje model (SANNBZ (Stewart–Aslanidi–Noble–Noble–Boyett–Zhang Purkinje cell model)). (a) Steady state inactivation curves (h∞) in the presence or absence of E3G. (b) and (c) Inhibitory effect of E3G on the sodium current at −90 mV and −70 mV resting potentials. (d) Inhibitory effect of E3G on the calcium current (20% inhibition). (e) Inhibitory effect of E3G on the current (25% inhibition: dashed line; 50% inhibition: solid line). (f) E3G effect on the Purkinje action potential (intensity of stimulus = 52 μA/μF, duration: 1 ms; inset, zoom of the rapid depolarization phase). For all panels, black lines: without E3G; red lines: 30 μM E3G.
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