Review Article

Artificial Neural Networks in Image Processing for Early Detection of Breast Cancer

Table 1

Summary of methods with NN in breast cancer detection.

StudyMethodsInputPurposeDatasetClassifierResults

Dheeba et al. [3]Particle Swarm Optimized Wavelet Neural Network (PSOWNN)MammogramImprove classification accuracy in breast cancer detection and reducing misclassification rate216 mammogramsPSOWNN(i) Sensitivity 94.167%
(ii) Specificity 92.105%
(iii) AUC 0.96853
(iv) Youden’s index 0.86272
(v) Misclassification rate 0.063291

Xu et al. [10]New algorithm based on two ANNsMammogramClassification of masses30 cases and 60 mammograms
(containing 78 masses)
ANFIS and MLP(i) True positive (TP) rate 93.6% (73/78),
(ii) Number of the FPs per image 0.63 (38/60).

Alayliogh and Aghdasi [11]ANN and biorthogonal spline waveletMammogramClassification of microcalcification cluster (MCC) and image enhancement40 digitized mammogramANN(i) Sensitivity 93%,
(ii) FP rate (MCC/image) 0.82

Dhawan et al. [13](i) ANN
(ii) second-order gray-level statistics
MammogramClassification of significant and benign microcalcifications5 image structure features(i) Three-layer perceptron based ANNThe entropy feature has significant discriminating power for classification

Chitre et al. [15]ANNMammogramClassification of microcalcification into benign and malignant(i) 40, 60, and 80 training cases
(ii) 151, 131, and 111 test cases
ANNNeural network is a robust classifier of a combination of image structure and binary features into benign and malignant

Kevin et al. [16]ANNMammogramClassification of microcalcifications and nonmicrocalcifications24 mammograms with
each containing at least one cluster of microcalcifications
Cascade correlation ANN
(CC ANN)
(i) TP detection rate for individual
microcalcifications is 73% and 92% for nonmicrocalcifications

Zheng et al. [18]ANN and BBNMammogramCompare performances of ANN and BBN3 independent image databases and 38 featuresANN and BBNPerformance level ( value)
(i) ANN value (ii) BBN value 0.845 ± 0.011
(iii) Hybrid classifier (ANN and BBN)
Az value increased to 0.859 ± 0.01

Zhang et al. [19]Digitize module, detection module, feature extraction module, neural network module, and classification moduleMammogramClassification of microcalcification clusters/suspicious areasFuzzy detection algorithm
(i) 30 digital images (15 contain benign cases and 15 contain malignant cases)
Backpropagation neural network (BPNN)(i) Fuzzy detection rate (benign 84.10% and 80.30%)
(ii) Classification rates (feature vector, is 83.8%), (feature vector is 72.2%)

Lashkari [20]ANN and Gabor waveletsMammogramClassification of breast tissues to normal and abnormal classes automatically(i) Images of 50 normal and 50
abnormal breast tissues
(ii) 65 cases for training set and 35 cases for testing set
ANN and Gabor wavelets(i) Classification rate (testing performance 96.3% and training performance 97.5%)

Saini and Vijay [17]Image registration technique and ANNMammogramClassification of benign and malignant42 mammogram images (30 benign and 12 malignant images)Feed-forward backpropagation and Cascade forward
backpropagation artificial neural network
Percentage accuracy
(feed-forward
backpropagation network is 87.5% and Cascade forward
backpropagation network is 67.8%)

Buller et al. [21]Spider web topology with NNUltrasoundClassify and separate benign and malignant lesion25 sonograms(i) NN classifier(i) 69% accuracy in malignant
(ii) 66% accuracy in benign
(iii) 66% accuracy in no lesions

Ruggierol et al. [22]Texture and shape parameter feeds into NNUltrasoundAutomated recognition of malignant lesion(i) 41 carcinomas
(ii) 41 fibroadenomas
(iii) 41 cysts
(i) NN classifier(i) 95% accuracy in solid lesions
(ii) 92.7% accuracy in liquid lesions

Sahiner et al. [23]Convolutional NN with spatial and texture imageMammogramClassification of mass and normal breast168 mammograms(i) Convolution NN classifier(i) Average true positive fraction of 90% at false positive fraction of 31%

Chen et al. [24]Multilayer feed-forward neural network (MFNN)UltrasoundClassify benign and malignant lesion140 pathological proved tumors (52 malignant, 88 benign)MFNN(i) 95% accuracy, 98% sensitivity
(ii) 93% specificity
(iii) 89% positive predictive value
(iv) 99% negative predictive value

Chen et al. [25]Self-organizing map (SOM)UltrasoundClassification of benign and malignant lesions243 tumors (82 malignant, 161 benign)SOM(i) Accuracy of 85.6, sensitivity 97.6%
(ii) Specificity 79.5%
(iii) Positive predictive value 70.8%
(iv) Negative predictive value 98.5%

Chen et al. [27]Bootstrap with NNUltrasoundclassification of tumor263 sonographic image solid breast nodulesNN(i) Accuracy 87.07%, sensitivity 98.35%
(ii) Specificity 79.10%
(iii) Positive predictive value 81.46%
(iv) Negative predictive value 94.64%

Chen et al. [26]2-phase Hierarchical Neural Network (HNN)UltrasoundDifferentiate between benign and malignant tumors1020 images (4 different rectangular regions from the 2 orthogonal planes of each tumor)HNN4 image analyses of each tumor appear to give more promising result than if they are used separately

Chen et al. [28]Wavelet transform and neural networkUltrasoundDifferential diagnosis of breast tumors on sonograms242 cases (161 benign, 82 malignant)Multilayer perceptron neural network (MLPNN)(i) Receiver operating characteristic (ROC) area index is 0.9396 ± 0.0183
(ii) 98.77% sensitivity, 81.37% specificity
(iii) 72.73% positive predictive value
(iv) 99.24% negative predictive value

Chen et al. [29]Multilayer feed-forward neural network (MFNN)UltrasoundDifferentiate benign from malignant breast lesions1st set: 160 lesions
2nd set: 111 lesions
MFNN(i) 98.2% training accuracy
(ii) 95.5% testing accuracy

Joo et al. [30]Artificial neural network (ANN)UltrasoundDetermining whether a breast nodule is benign or malignant584 histologically confirmed cases (300 benign, 284 malignant)ANN(i) 100% training accuracy
(ii) 91.4% testing set
(iii) 92.3% sensitivity, 90.7% specificity

Joo et al. [31]Digital image processing and artificial neural networkUltrasoundDetermine breast nodule malignancy584 histologically confirmed cases (300 benign, 284 malignant)ANN(i) 91.4% accuracy, 92.3% sensitivity
(ii) 90.7% specificity

Zheng et al. [32]Hybrid method (unsupervised k-means cluster, supervised backpropagation neural network (BPNN))UltrasoundClassification of breast tumors as benign or malignant125 benign tumors, 110 malignant tumorsCombination of k-means with BPNN(i) Recognition rate (94.5% for benign, 93.6% for malignant)
(ii) 94% accuracy, 94.5% sensitivity
(iii) 93.6% specificity

Fok et al. [35]ANN with 3D finite element analysisIRTumor prediction200 patientsANNGood detection, poor sensitivity

Szu et al. [36]Unsupervised classification using Lagrange Constraint Neural Network (LCNN)Mid and long IR imagesEarly detection of breast cancerOne patient with DCISLCNNBetter sensitivity

Jakubowska et al. [37]ANN with wavelet transformIR Discrimination of healthy and pathological cases30 healthyANNAccuracy (%)
(frontal/side)
Raw: 90/93, PCA: 90/93
LDA: 93/97, NDA: 93/93
10 with recognized tumorsAccuracy (%)
(frontal/side)
Raw: 80/90, PCA: 80/90
LDA: 90/90, NDA: 80/100

Koay et al. [33]Backpropagation NNIREarly detection of breast cancer19 patientsLevenberg-Marquardt (LM) and Resilient Backpropagation (RP)Accuracy (%)
(RP/LM)
Whole:
95/95
Quadrants: 95/100

Tan et al. [34]Fuzzy adaptive learning control network fuzzy neural networkIREarly detection of breast cancer and tumor classification28 healthy, 43 benign tumors, 7 cancer patientsFALCON-AARTCancer detection (%) (TH/TDF)
Predicted: 95, sensitivity: 100, specificity: 60
Breast tumor detection (%) (TH/TDF)
Predicted: 84/71, sensitivity: 33/76,
specificity: 91/62
Breast tumor classification (%) (TH/TDF)
Predicted: 88/84, sensitivity: 33/33,
specificity: 95.5/91

Cardillo et al. [40]NN for automatic analysis of image statisticsMRIEarly detection and classification150 exams subdivided into 6 groups by contrastNNBetter in specificity

Tzacheva et al. [41]Evaluation of signal intensity and mass properties by NNMRIAutomatic diagnosis of tumors14 patientsFeed-forward BPNN90%–100% sensitivity, 91%–100% specificity, and 91%–100% accuracy

Ertas et al. [39]Extraction of breast regions by conventional and multistate CNNsMRIBreast density evaluation and abnormality localization23 womenCNNAverage precision 99.3 ± 1.8%
True positive volume fraction 99.5 ± 1.3%
False positive volume fraction 0.1 ± 0.2%

Hassanien et al. [38]Image classification using PCNN and SVM and using wavelet and fuzzy sets for enhancementMRIBreast cancer detection70 normal cases, 50 benign and malign casesHybrid scheme of PCNN and SVMAccuracy
SVM: 98%
Rough sets: 92%

ElNawasany et al. [42]Classifying MR images by hybrid perceptron NNMRIEarly detection of breast cancer138 abnormal and 143 normalPerceptron with SIFTAccuracy 86.74%