Periodically Pulsed Immunotherapy in a Mathematical Model of Tumor, CD4<sup>+</sup> T Cells, and Antitumor Cytokine Interactions

<div>The pictures (a) and (b) represent the evolution of the tumor for <span class="nowrap"><svg height="12.7178pt" id="M349" style="vertical-align:-3.42947pt" version="1.1" viewbox="-0.0498162 -9.28833 50.633 12.7178" width="50.633pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M558 587C558 666 497 712 432 712C379 712 330 691 284 650C212 586 178 508 148 348L71 -65C49 -185 35 -229 23 -235L27 -261C49 -259 101 -251 124 -224C131 -216 138 -178 159 -24C171 66 197 200 227 356C264 550 295 668 393 668C443 668 479 632 479 575C479 516 446 458 383 418C361 404 344 398 318 397L296 350C395 338 460 281 460 192C460 110 411 40 300 40C258 40 215 55 192 69L181 51C191 18 222 -16 266 -16C308 -16 351 1 397 26C471 67 545 142 545 221C545 315 486 365 401 395C469 437 558 498 558 587Z" id="g113-224"></path></g><g transform="matrix(.013,0,0,-0.013,11.186,0)"><path d="M535 323V373H52V323H535ZM535 138V188H52V138H535Z" 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transform="matrix(.013,0,0,-0.013,44.133,0)"><path d="M153 550H386L412 615L406 623H120L82 318C104 327 142 338 184 338C294 338 347 275 347 187C347 112 305 39 221 39C160 39 119 71 97 89C88 97 80 96 71 90C59 80 50 67 49 57C48 45 52 36 66 23C80 9 123 -12 169 -12C221 -11 288 15 342 59C403 109 431 165 431 225C431 308 366 395 238 395C212 395 165 379 127 364L153 550Z" id="g113-54"></path></g></svg>.</span> The initial condition is <span class="nowrap"><svg height="11.439pt" id="M350" style="vertical-align:-2.15067pt" version="1.1" viewbox="-0.0498162 -9.28833 62.9423 11.439" width="62.9423pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M290 -163V-135C183 -126 181 -122 181 -44V583C181 662 184 666 290 675V703H120V-163H290Z" id="g113-92"></path></g><g transform="matrix(.013,0,0,-0.013,4.485,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 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Computational and Mathematical Methods in Medicine

fig8

Figure 8

Figure 8: Periodically Pulsed Immunotherapy in a Mathematical Model of Tumor, CD4<sup>+</sup> T Cells, and Antitumor Cytokine Interactions 

Computational and Mathematical Methods in Medicine

Periodically Pulsed Immunotherapy in a Mathematical Model of Tumor, CD4+ T Cells, and Antitumor Cytokine Interactions

Figure 8

Periodically Pulsed Immunotherapy in a Mathematical Model of Tumor, CD4⁺ T Cells, and Antitumor Cytokine Interactions