Pathway Interaction Network Analysis Identifies Dysregulated Pathways in Human Monocytes Infected by Listeria monocytogenes

Figure 1

Workflow of detection of dysregulated pathways in LM-infected samples. Specifically, gene expression profile of human peripheral monocytes infected by LM (accession number E-MEXP-1613), cellular pathways, and human PPIs were, respectively, obtained from the corresponding databases. The PIN was constructed with each node standing for a cellular pathway on the basis of gene expression profile, PPIs, and cellular pathways. Finally, identifying dysregulated pathways from PIN was performed according to seed pathway and classification accuracy. The red node represented the firstly identified pathway called seed pathway, and the blue ones were those pathway markers that were combined with the seed pathway to obtain best classification accuracy while discriminating between LM-infected samples and controls.