Defining an Optimal Cut-Point Value in ROC Analysis: An Alternative Approach

Table 9

The true cut-point estimates obtained by all the methods: some of cut-points and the AUC values for pulse pressure, LVEF, plasma sodium level and heart rate in prediction of mortality.

	Pulse pressure	LVEF	Plasma sodium	Heart rate
	Point (Se, Sp)	Point (Se, Sp)	Point (Se, Sp)	Point (Se, Sp)
Youden index	30 (83.7, 79.7)	0.264 (62.8, 84.7)	137 (93.0, 48.3)	99 (32.6, 91.5)
ER	30 (83.7, 79.7)	0.295 (76.7, 69.5)	135 (72.1, 66.9)	85 (62.8, 58.5)
Min value	24 (98.3, 53.5)	0.235 (46.5, 94.9)	130 (39.5, 92.4)	115 (16.3, 99.2)
CZ	30 (83.7, 79.7)	0.295 (76.7, 69.5)	135 (72.1, 66.9)	85 (62.8, 58.5)
Some cut-off points with their sensitivity and specificity values	24 (53.5, 98.3); 27 (81.4, 79.7); 30 (83.7, 79.7); 34 (83.7, 77.1); 37 (100, 39.0); …	0.272 (65.1, 81.4); 0.282 (67.4, 76.3); 0.290 (69.8, 75.4); 0.295 (76.7, 69.5); 0.303 (81.4, 61.0)	133 (53.5, 82.2); 134 (60.5, 76.3); 135 (72.1, 66.9); 136 (81.4, 57.6); 137 (93.0, 48.3)	84 (67.4, 53.4); 85 (62.8, 58.5); 86 (58.1, 61.9); 87 (51.2, 68.6)
Index of Union	30 (83.7, 79.7)	0.295 (76.7, 69.5)	135 (72.1, 66.9)	85 (62.8, 58.5)
AUC	0.892	0.809	0.777	0.647

Note. Point: cut-point; Se: sensitivity; Sp: specificity; AUC: the area under the curve.