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Computational and Mathematical Methods in Medicine
Volume 2017, Article ID 5235319, 5 pages
Research Article

Increase of Short-Term Heart Rate Variability Induced by Blood Pressure Measurements during Ambulatory Blood Pressure Monitoring

1Department of Internal Medicine IV, University of Medicine and Pharmacy of Tîrgu Mureș, Tîrgu Mureș, Romania
2Department of Cardiology I, Victor Babeș University of Medicine and Pharmacy, Timișoara, Timișioara, Romania
3BioTech Research Center, Óbuda University, Budapest, Hungary
4Faculty of Technical and Human Sciences, Sapientia Hungarian University of Transylvania, Tîrgu Mureș, Romania
5Department of Control Engineering and Information Technology, Budapest University of Technology and Economics, Budapest, Hungary

Correspondence should be addressed to Attila Frigy; moc.liamg@86ygirfa

Received 19 December 2016; Revised 5 March 2017; Accepted 20 March 2017; Published 3 April 2017

Academic Editor: Luca Faes

Copyright © 2017 Attila Frigy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. The possible effect of blood pressure measurements per se on heart rate variability (HRV) was studied in the setting of concomitant ambulatory blood pressure monitoring (ABPM) and Holter ECG monitoring (HM). Methods. In 25 hypertensive patients (14 women and 11 men, mean age: 58.1 years), 24-hour combined ABPM and HM were performed. For every blood pressure measurement, 2-minute ECG segments (before, during, and after measurement) were analyzed to obtain time domain parameters of HRV: SDNN and rMSSD. Mean of normal RR intervals (MNN), SDNN/MNN, and rMSSD/MNN were calculated, too. Parameter variations related to blood pressure measurements were analyzed using one-way ANOVA with multiple comparisons. Results. 2281 measurements (1518 during the day and 763 during the night) were included in the analysis. Both SDNN and SDNN/MNN had a constant (the same for 24-hour, daytime, and nighttime values) and significant change related to blood pressure measurements: an increase during measurements and a decrease after them ( for any variation). Conclusion. In the setting of combined ABPM and HM, the blood pressure measurement itself produces an increase in short-term heart rate variability. Clarifying the physiological basis and the possible clinical value of this phenomenon needs further studies.