TY - JOUR A2 - Rychtar, Jan AU - Phan, Tuan Anh AU - Tian, Jianjun Paul PY - 2017 DA - 2017/12/12 TI - The Role of the Innate Immune System in Oncolytic Virotherapy SP - 6587258 VL - 2017 AB - The complexity of the immune responses is a major challenge in current virotherapy. This study incorporates the innate immune response into our basic model for virotherapy and investigates how the innate immunity affects the outcome of virotherapy. The viral therapeutic dynamics is largely determined by the viral burst size, relative innate immune killing rate, and relative innate immunity decay rate. The innate immunity may complicate virotherapy in the way of creating more equilibria when the viral burst size is not too big, while the dynamics is similar to the system without innate immunity when the viral burst size is big. SN - 1748-670X UR - https://doi.org/10.1155/2017/6587258 DO - 10.1155/2017/6587258 JF - Computational and Mathematical Methods in Medicine PB - Hindawi KW - ER -