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Computational and Mathematical Methods in Medicine
Volume 2017, Article ID 6810626, 11 pages
https://doi.org/10.1155/2017/6810626
Research Article

Optimally Repeatable Kinetic Model Variant for Myocardial Blood Flow Measurements with 82Rb PET

1Systems and Computer Engineering, Carleton University, Ottawa, ON, Canada
2National Cardiac PET Centre, Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, ON, Canada
3Department of Nuclear Medicine, The Ottawa Hospital, Ottawa, ON, Canada
4Division of Nuclear Medicine, Department of Medicine, University of Ottawa, Ottawa, ON, Canada

Correspondence should be addressed to Adrian F. Ocneanu; ac.traehawatto@unaencoa

Received 11 September 2016; Accepted 24 November 2016; Published 13 February 2017

Academic Editor: Thomas Desaive

Copyright © 2017 Adrian F. Ocneanu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose. Myocardial blood flow (MBF) quantification with positron emission tomography (PET) is gaining clinical adoption, but improvements in precision are desired. This study aims to identify analysis variants producing the most repeatable MBF measures. Methods. 12 volunteers underwent same-day test-retest rest and dipyridamole stress imaging with dynamic PET, from which MBF was quantified using 1-tissue-compartment kinetic model variants: () blood-pool versus uptake region sampled input function (Blood/Uptake-ROI), () dual spillover correction (SOC-On/Off), () right blood correction (RBC-On/Off), () arterial blood transit delay (Delay-On/Off), and () distribution volume (DV) constraint (Global/Regional-DV). Repeatability of MBF, stress/rest myocardial flow reserve (MFR), and stress/rest MBF difference (ΔMBF) was assessed using nonparametric reproducibility coefficients ( = 1.45 × interquartile range). Results. MBF using SOC-On, RVBC-Off, Blood-ROI, Global-DV, and Delay-Off was most repeatable for combined rest and stress: = 0.21 mL/min/g (15.8%). Corresponding MFR and ΔMBF were 0.42 (20.2%) and 0.24 mL/min/g (23.5%). MBF repeatability improved with SOC-On at stress () and tended to improve with RBC-Off at both rest and stress (). DV and ROI did not significantly influence repeatability. The Delay-On model was overdetermined and did not reliably converge. Conclusion. MBF and MFR test-retest repeatability were the best with dual spillover correction, left atrium blood input function, and global DV.