Biomarker MicroRNAs for Diagnosis of Oral Squamous Cell Carcinoma Identified Based on Gene Expression Data and MicroRNA-mRNA Network Analysis

Table 2

Previously reported microRNA biomarkers for OSCC from PubMed.

MicroRNA	PMID	Biomarker Type	Samples	Expression in OSCC	NOD; (Ref.)	TFP; (Ref.)
miR-155-5p	26307116; 24692283	Prognostic biomarker	Tissue	Upregulated	71	0.211
miR-483-5p	26224475	Diagnostic/prognostic biomarker	Serum	Upregulated	4	0.135
miR-216a	25955794	Prognostic biomarker	Tissue	Downregulated	6	0.087
miR-21-3p; miR-96-5p; miR-141-3p; miR-130b-3p	25532855	Prognostic biomarker	Tissue	Upregulated	N/A; 8; 22; 2	N/A; 0.159; 0.167; 0.119
miR-21-5p	24755828	Prognostic biomarker	Tissue	Upregulated	38	0.135
miR-31-5p	22083872	Diagnostic biomarker	Saliva	Upregulated	10	0.142

The NOD and TFP are calculated based on the reference human microRNA-mRNA network, while the measurements in Section 3.2 are calculated based on the OSCC-specific network.