Quantitative Assessment of the Physiological Parameters Influencing QT Interval Response to Medication: Application of Computational Intelligence Tools

Table 1

The summary of the data set.

Input number	Labels	Min	1st quantile	Median	Mean	3rd quantile	Max
(1)	CYP1A2	0	0	0	695159	0	11963910
(2)	CYP2A6	0	0	0	0	0	0
(3)	CYP2B6	0	0	0	86155	0	9129915
(4)	CYP2C8	0	0	0	0	0	0
(5)	CYP2C9	0	0	0	347459	0	16469809
(6)	CYP2C18	0	0	0	0	0	0
(7)	CYP2C19	0	0	0	179400	0	5511004
(8)	CYP2D6	0	252231	399478	506695	676312	2185456
(9)	CYP2E1	0	0	0	0	0	0
(10)	CYP2J2	0	0	0	0	0	0
(11)	CYP3A4	1552693	5716140	8459929	9833766	12016781	32307836
(12)	CYP3A5	0	0	0	272853	0	13728653
(13)	CYP3A7	0	0	0	0	0	0
(14)	Gut_CYP2C9	8210	1430	10037.216	10089.122	10148.391	10388.032
(15)	Gut_CYP2C19	0	0	0	299	0	7330
(16)	Gut_CYP2D6	0	484.7	674.4	818.4	994.5	3156
(17)	Gut_CYP2J2	0	0	0	0	0	0
(18)	Gut_CYP3A4	11214	35540	55975	62911	80376	217447
(19)	Gut_CYP3A5	0	0	0	807.2	0	55106.1
(20)	Sex_Code	0	1	1	0.7718	1	1
(21)	Age	19	25	28	28.39	32	52
(22)	Weight	44.52	69.43	78.31	79.04	89.17	127
(23)	Height	149.4	168.6	174.3	173.6	179.7	200.5
(24)	BSA	1.422	1.802	1.937	1.929	2.048	2.432
(25)	Brain_Weight	1040	1230	1354	1388	1524	2057
(26)	Kidney_Weight	164.1	269.1	325	329.1	382.6	752
(27)	Liver_Weight	1052	1544	1700	1740	1938	2699
(28)	BMI	16.13	22.87	26.22	26.19	28.8	45.31
(29)	Cardiac_Output	249.7	315.1	339.4	337.5	357.2	424.5
(30)	Haematocrit	32.12	38.99	41.73	41.46	43.68	51.05
(31)	HSA	35.11	42.88	45.74	45.75	48.57	58.08
(32)	AGP	0.3971	0.7137	0.8035	0.7982	0.8851	1.207
(33)	Serum_Creatinine	33.64	62.09	73.26	72.61	81.2	122.95
(34)	GFR	70.97	112.12	129.74	133.34	153.5	243.16
(35)	Renal_Function	0.59	0.92	1.079	1.089	1.271	1.87
(36)	Cardiomyocyte_area	652.5	1384.3	1701.1	1824.4	2146.8	5353.7
(37)	Cardiomyocyte_volume	1852	4494	5630	6217	7346	20339
(38)	Sarcoplasmic_reticulum_volume	111.1	269.6	337.8	373	440.7	1220.3
(39)	Capacitance	17.33	36.77	45.18	48.46	57.02	142.2
(40)	String_length	0.8772	1.1814	1.293	1.2878	1.4064	1.8619
(41)	K	3.053	4.079	4.268	4.261	4.451	5.363
(42)	Na	135.1	139.6	140.4	140.3	141.1	143.3
(43)	Ca2	2.007	2.237	2.388	2.394	2.546	2.789
(44)	IKr_inhibition	0.0047	0.0484	0.1172	0.2378	0.3841	1
(45)	IKs_inhibition	0			0.0002684	0.0003	0.008
(46)	INa_inhibition	0	0.0003	0.0007	0.001493	0.0016	0.0353
(47)	ICa_inhibition	0	0.0009	0.0022	0.01782	0.0061	0.5217
(48)	Stimulation_Period	432	735	825	836.1	925	1570
Output	dQTc	−15.707	1.713	6.591	10.572	14.69	78.142

Where CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2D6, CYP2E1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, corresponding patients’ abundance of cytochromes in the liver [pmol/mg of protein]; Gut_CYP2C9, Gut_CYP2C19, Gut_CYP2D6, Gut_CYP2J2, Gut_CYP3A4, Gut_CYP3A5, corresponding patients’ abundance of cytochromes in the gut [nmol/small intestine]; Sex_Code, patients’ gender [male = 0/female = 1]; Age, patients’ age [years]; Weight, patients’ weight [kg]; Height, patients’ height [cm]; BSA, patients’ body surface area [m²]; Brain_Weight, patients’ brain weight [g]; Kidney_Weight, patients’ kidney weight [g]; Liver_Weight, patients’ liver weight [g]; BMI, patients’ body mass index; Cardiac_Output, patients’ cardiac output [L/h]; Haematocrit, patients’ specific haematocrit [%]; HSA, AGP, patients’ specific level of human serum albumin and alfa-acid glycoproteins in the plasma [g/L]; Serum_Creatinine, patients’ specific creatinine level [μmol/L]; GFR, the Glomerular Filtration Rates of the simulated individual (mL/min/1.73 m²); Renal_Function, the ratio of individual’s GFR to that of the normal value of 120 mL/min/1.73 m² for male or 130 mL/min/1.73 m² for female; Cardiomyocyte_area, patients’ specific area of the cardiac myocyte [μm²]; Cardiomyocyte_volume, patients’ specific volume of the cardiac myocyte [μm³]; Sarcoplasmic_reticulum_volume, patients’ specific volume of the cardiac myocyte sarcoplasmic reticulum [μm³]; Capacitance, patients’ specific cardiac myocyte electric capacitance [pF]; String_length, patients’ specific thickness of the left heart wall [cm]; K, Na, Ca2, patients’ specific concentration of ions in plasma [mM]; IKr_inhibition, IKs_inhibition, INa_inhibition, ICa_inhibition, patients’ and drugs’ specific ionic current inhibition; Stimulation_Period, time gaps between stimulaitons [ms]; dQTc, patients’ QTc interval modification as compared against baseline.