Explicit Theoretical Analysis of How the Rate of Exocytosis Depends on Local Control by Ca²⁺ Channels

Figure 3

Expected exocytosis rate for single granule coupled with k (inactivating or non-inactivating) CaVs. (a–d) and (f–i) Expected exocytosis rate for the granule at fixed distance from k ( (blue curves), (magenta), (cyan), and (black)) inactivating/not-inactivating CaVs: nm (a/f), 20 nm (b/g), 30 nm (c/h), and 50 nm (d/i). The insert in (f) is a zoom on the lower, left part of the figure for comparison with (a). (e) and (j) Relative rate obtained from the granule coupled with k inactivating/not-inactivating CaVs (e/j), for (blue), (magenta), and (cyan) and compared to the case with CaVs. The different type of line corresponds to computed at fixed distance: nm (solid line), nm (dashed), nm (dash-dotted), and nm (dotted).

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