Computational and Mathematical Methods in Medicine

Research Article

Evaluation of the Feasibility of Screening Tau Radiotracers Using an Amyloid Biomathematical Screening Methodology

Table 3

Comparison of predicted (literature-reported and default time window of 90–110 min) and clinically observed SUVR (highest SUVR in AD) of HC and AD conditions.


Clinically applied radiotracers	Predicted SUVR				Clinically observed SUVR
	Default		Literature		Highest in AD		Regions	Time window (min)	References
	HC	AD	HC	AD	HC	AD	Regions	Time window (min)	References

[¹⁸F]THK523	1.00	1.01	1.00	1.01	0.96	1.81	ITL	60–90	[32]
[¹⁸F]THK5105	1.03	1.34	1.03	1.35	1.41	1.52	PU	90–100	[33]
[¹⁸F]THK5117	1.04	1.47	1.05	1.56	1.57	1.77	PU	50–60	[34]
[¹⁸F]THK5317	1.01	1.13	1.01	1.14	—	—	—	—	—
[¹⁸F]THK5351	1.10	2.11	1.11	2.38	2.14	2.98	HIP	50–60	[15]
[¹⁸F]flortaucipir	1.03	1.35	1.03	1.35	1.17	2.19	ITL	80–100	[40]
[¹⁸F]T808	1.00	1.02	1.00	1.02	0.94	1.52	LTL	80–100	[35]
[¹¹C]PBB3	1.04	1.43	1.05	1.55	0.85	1.42	Global^#	30–50	[10]
[¹⁸F]FDDNP	1.00	1.03	1.00	1.04	1.24	1.37	ACG	45–55	[41]
[¹⁸F]MK6240	1.78	9.94	1.78	9.93	—	∼5	PRE	90–110	[16]

ITL = inferior temporal lobe, LTL = lateral temporal lobe, PU = putamen, PAR = parietal lobe, HIP = hippocampus, ACG = anterior posterior cingulate, PRE = precuneus. ^#Global = cerebral cortex for HC and high binding ROI for AD. SUVR is approximated from the plot, taking the highest SUVR in AD.