Research Article

Maximin Efficiencies under Treatment-Dependent Costs and Outcome Variances for Parallel, AA/BB, and AB/BA Designs

Table 6


Treatment by period interaction
NCrossover designExtended parallel design

Type I error rate = 0.05
[0.01, 0.10][0.01, 0.10]1100.799 (0.90)0.840 (1)
[0.01, 0.30][0.01, 0.30]1300.801 (0.76)0.899 (1)
[0.70, 1.00][0.70, 1.00]340.206 (0.15)0.830 (1)
[0.90, 1.00][0.90, 1.00]150.111 (0.05)0.883 (1)

Type I error rate = 0.01
[0.01, 0.10][0.01, 0.10]1660.808 (0.90)0.848 (1)
[0.01, 0.30][0.01, 0.30]1940.800 (0.76)0.912 (1)
[0.70, 1.00][0.70, 1.00]510.117 (0.15)0.840 (1)
[0.90, 1.00][0.90, 1.00]230.048 (0.05)0.911 (1)

Note. The power printed in bold indicates the design for which the sample calculation should yield a power of 80%. N: total sample size.