Developing a Minimally Structured Mathematical Model of Cancer Treatment with Oncolytic Viruses and Dendritic Cell Injections

Figure 6

VEPART output at the low OV/high DC dose. The x axis indicates each of the 20 treatment protocols tested, with “V” representing Ad/4-1BBL/IL-12 treatment and “D” representing DC treatment on a given day. For each of the 20 treatment protocols, we see the frequency of virtual populations for which the specified treatment protocol leads to tumor eradication (blue) or tumor escape (yellow) for (a) the original model in system (1)–(6), and (b) the minimal model in system (11)–(15).

(a)

(b)