Likelihood-Ratio-Test Methods for Drug Safety Signal Detection from Multiple Clinical Datasets

Table 1

Statistics in different methods (j is fixed and drop suffix j in the following formulation). Either logLR or LR can be used. In addition to the most significant signal, secondary signals can also be identified.

Method	logLR or weighted logLR	Test statistic (STAT)	Most significant signal detected
Pooled			a row
MMLR			a row-study combination
wLRn			a row