Improved Specificity and False Discovery Rates for Multiplex Analysis of Changes in Strain-Specific Anti-Influenza IgG

Figure 5

Simulation results on total rejection, FDR, sensitivity, and specificity under different simulation settings with sample size of 15 in each group. The FDRs for comparing different groups were markedly smaller when the strain subtype variations were considered in the data analysis, especially when the proportion of true differences between treatment groups () were small. The specificities were much larger when the strain subtype differences were taken into account.