Computational Causal Modeling of the Dynamic Biomarker Cascade in Alzheimer’s Disease

Figure 2

Model of early-onset, autosomal dominant AD. The red, blue, and yellow curves represent the evolution of amyloid, tau, and neuronal biomarker levels, respectively, over the course of the disease. The green curves represent cognition in two hypothetical high- and low-risk groups based on low and high cognitive reserve. Our CCM-generated curves (b) closely match the schematic model curves (a) (adapted from [6] with permission) from the prior literature.

(a)

(b)