The Effect of CT Scan Parameters on the Measurement of CT Radiomic Features: A Lung Nodule Phantom Study

Table 2

Regression coefficients in the comparison between different slice thickness, mAs, and reconstruction algorithm in 100 HU nodule phantoms.

Image features			Constant	Slice thickness			mAs		Reconstruction algorithm
				5.00 (ref.)	2.50	1.25	30 (ref.)	120	Lung (ref.)	Standard
Histogram		Mean	0.323	0	0.418^†	0.613^†	0	0.020^†	0	−0.271^†
		Stddev	0.442	0	−0.085^†	−0.237^†	0	−0.055^†	0	−0.075^†
		Variance	0.260	0	−0.058^†	−0.152^†	0	−0.036^†	0	−0.047^†
		Skewness	0.008	0	0.179^†	0.463^†	0	0.051^†	0	0.108^†
		Kurtosis	0.772	0	−0.135^†	−0.177^†	0	−0.032	0	−0.234^†
		Energy	0.112	0	0.388^†	0.642^†	0	0.103^†	0	−0.209^†
		Entropy	0.814	0	−0.430^†	−0.664^†	0	−0.079^†	0	0.188^†
GLCM		Contrast	0.078	0	0.171^†	0.383^†	0	−0.022^†	0	−0.026^†
		Dissimilarity	0.231	0	0.011	0.135^†	0	−0.058^†	0	0.036^†
		Homogeneity	0.147	0	0.472^†	0.600^†	0	0.131^†	0	−0.127^†
		ASM	0.025	0	0.387^†	0.552^†	0	0.186^†	0	−0.159^†
		Energy	0.130	0	0.476^†	0.614^†	0	0.142^†	0	−0.145^†
		Probability max	0.150	0	0.466^†	0.583^†	0	0.141^†	0	−0.137^†
		Entropy	0.856	0	−0.454^†	−0.646^†	0	−0.116^†	0	0.153^†
		Correlation	0.927	0	−0.129^†	−0.299^†	0	0.026^†	0	0.015
GLRLM		LRE	0.036	0	0.452^†	0.574^†	0	0.178^†	0	−0.097^†
		GLN	0.105	0	0.418^†	0.621^†	0	0.117^†	0	−0.181^†
		RLN	0.745	0	−0.541^†	−0.636^†	0	−0.105^†	0	0.116^†
		LGRE	0.212	0	−0.130^†	−0.180^†	0	−0.011	0	0.037^†
		HGRE	0.288	0	0.509^†	0.672^†	0	0.039^†	0	−0.161^†

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