The Effect of CT Scan Parameters on the Measurement of CT Radiomic Features: A Lung Nodule Phantom Study

Table 4

Regression coefficients in the comparison between different slice thickness, mAs, and reconstruction algorithm in −630 HU nodule phantoms.

Image features			Constant	Slice thickness			mAs		Reconstruction algorithm
				5.00 (ref.)	2.50	1.25	30 (ref.)	120	Lung (ref.)	Standard
Histogram		Mean	0.617	0	0.247^†	0.277^†	0	−0.011	0	−0.154^†
		Stddev	0.369	0	0.036	0.158^†	0	−0.149^†	0	−0.279^†
		Variance	0.230	0	0.034	0.154^†	0	−0.125^†	0	−0.200^†
		Skewness	−0.023	0	0.209^†	0.256^†	0	0.143^†	0	0.224^†
		Kurtosis	0.985	0	−0.146^†	−0.098^†	0	−0.149^†	0	−0.436^†
		Energy	0.061	0	0.063^†	−0.021	0	0.189^†	0	0.361^†
		Entropy	0.664	0	0.014	0.122^†	0	−0.196^†	0	−0.394^†
GLCM		Contrast	0.237	0	0.111^†	0.238^†	0	−0.108^†	0	−0.206^†
		Dissimilarity	0.349	0	0.121^†	0.251^†	0	−0.141^†	0	−0.292^†
		Homogeneity	0.193	0	−0.039^†	−0.154^†	0	0.191^†	0	0.422^†
		ASM	0.027	0	−0.004	−0.060^†	0	0.109^†	0	0.166^†
		Energy	0.080	0	−0.015	−0.086^†	0	0.139^†	0	0.233^†
		Probability max	0.052	0	−0.008	−0.036^†	0	0.084^†	0	0.122^†
		Entropy	0.788	0	0.042	0.130^†	0	−0.153^†	0	−0.284^†
		Correlation	0.752	0	−0.100^†	−0.228^†	0	0.109^†	0	0.204^†
GLRLM		LRE	0.068	0	0.014	−0.054^†	0	0.130^†	0	0.258^†
		GLN	0.033	0	0.033^†	−0.018	0	0.125^†	0	0.223^†
		RLN	0.891	0	−0.004	0.078^†	0	−0.163^†	0	−0.318^†
		LGRE	0.167	0	−0.106^†	−0.086^†	0	−0.018	0	0.011
		HGRE	0.639	0	0.227^†	0.269^†	0	−0.030^†	0	−0.144^†

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