Holistic View on Cell Survival and DNA Damage: How Model-Based Data Analysis Supports Exploration of Dynamics in Biological Systems

Figure 5

Top: cell survival curves for two different sets of parameters after parameter search with clonogenic assay data. Two sets with similar errors were chosen (); the curves match experimental data (dots) relatively well and are very similar albeit having vastly different parameter values. Bottom: corresponding values in time (no hyperthermia). While the two parameter sets produce similar survival curves, the dynamics of repair are very different. Because clonogenic assay captures only the state after repair has completed, no information about these dynamics is in the data. The parameters are , , , , , , , and (set 1) and , , , , , , , and (set 2).