Bioinformatics analysis. Volcano plots were made to find the (a) DEmiRNAs and (b) DEmRNAs in TCGA-COAD dataset. (c) Survival analysis was performed, and it was found that miR-152-3p was of remarkable survival significance. (d) Venn diagram was plotted to find the candidate target genes from the predicted mRNAs of miR-152-3p and the DEmRNAs in TCGA-COAD dataset. (e) miR-152-3p was shown to be significantly upregulated in the colon cancer tissue in TCGA-COAD dataset. (f) KLF4 was verified to be noticeably lowly expressed in cancer tissue in TCGA-COAD dataset.