Identification of Mutator-Derived lncRNA Signatures of Genomic Instability for Promoting the Clinical Outcome in Hepatocellular Carcinoma

Figure 2

Screening for genome instability-associated lncRNAs (GIlncRNAs). (a) The heatmap of 88 genome instability-associated lncRNAs (GIlncRNAs). The left cyan is the genomic stability (GS) group, and the right red is the genomic instability (GI) group. (b) The unsupervised clustering of HCC patients through the expression model of 88 genome instability-associated lncRNAs. The left red is the genomic instability- (GI-) like group, and the right cyan is the genomic stability- (GS-) like group. (c) The boxplot of somatic mutation in the GS-like and GI-like groups, and the somatic mutation in the GS-like group is significantly lower than the GI-like group. (d) The TP-53 expression level in the GS-like and GI-like groups, and the TP-53 expression level in the GS-like group is significantly higher than the GI-like group.

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