Identification of Mutator-Derived lncRNA Signatures of Genomic Instability for Promoting the Clinical Outcome in Hepatocellular Carcinoma

Figure 7

Validation of the relationship between the GILncSig and the genomic instability. (a–c) The distribution of risk score, somatic mutation number, and UBQLN4 expression level. The dashed line presents the cutoff value, which divides HCC patients into the low-risk group and the high-risk group. Patients’ somatic mutation number and UBQLN4 expression level increased as the GILncSig score increased. (d, e) The boxplots of somatic mutation number and UBQLN4 expression level. The somatic mutation number and the UBQLN4 expression level in the high-risk group were higher than in the low-risk group. (f, g) The waterfall maps with associated mutation status of the high-risk and low-risk groups. The mutation frequency of TP53 in the high-risk group was 41%, which higher than 14% of the low-risk group.

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