Review Article

[Retracted] Second-Generation Tyrosine Kinase Inhibitor Discontinuation in Chronic Myeloid Leukemia Patients with Stable Deep Molecular Response: A Systematic Review and a Meta-Analysis

Table 3

Subgroup analysis of factors affecting recurrence.

CharacteristicsGroupingES (95% CI)

Sample size ()≤780.56 (0.44-0.67)64.4%
>780.51 (0.45-0.56)0%
Overall0.53 (0.47-0.60)47.1%
Female (%)≤49.50.52 (0.42-0.62)65.9%
>49.50.56 (0.48-0.63)0%
Overall0.53 (0.47-0.60)47.1%
Age (years)≤560.54 (0.46-0.61)51.6%
>560.52 (0.36-0.68)70.5%
Overall0.53 (0.47-0.60)47.1%
Previous therapyIFN/Ima0.61 (0.53-0.70)0%
Ima0.49 (0.44-0.55)0%
Overall0.53 (0.47-0.60)47.1%
Dasa or NiloDasa0.52 (0.36-0.68)70.5%
Nilo0.54 (0.46-0.61)51.6%
Overall0.53 (0.47-0.60)47.1%
2G-TKI median duration (month)≤310.52 (0.42-0.62)65.9%
>310.56 (0.48-0.63)0%
Overall0.53 (0.47-0.60)47.1%
Low Sokal score≤54.50.53 (0.43-0.64)58.2%
>54.40.54 (0.35-0.72)80.0%
Overall0.53 (0.47-0.60)47.1%
International or nationalInternational0.51 (0.45-0.56)0%
National0.56 (0.44-0.67)64.4%
Overall0.53 (0.47-0.60)47.1%
Quality assessmentH0.54 (0.46-0.61)51.6%
L0.52 (0.36-0.68)70.5%
Overall0.53 (0.47-0.60)47.1%