Ligand-Based and Docking-Based Virtual Screening of MDM2 Inhibitors as Potent Anticancer Agents

<div>Interactions of compounds AO-476/43250177 (a1, a2), AG-690/37072075 (b1, b2), AK-968/15254441 (c1, c2), AO-022/43452814 (d1, d2), and AF-399/25108021 (e1, e2) with MDM2. The amino acids interacting with the compounds are shown in a line form. Hydrogen bonds and hydrophobic interactions are shown in green and pink dashed lines, respectively.</div>

Computational and Mathematical Methods in Medicine

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Figure 4

Figure 4: Ligand-Based and Docking-Based Virtual Screening of MDM2 Inhibitors as Potent Anticancer Agents 