Ligand-Based and Docking-Based Virtual Screening of MDM2 Inhibitors as Potent Anticancer Agents

Table 2

Statistical parameters and enrichment scores for validation of MDM2 pharmacophore model.

Parameters	Values
	Hypo 02	Hypo 04
Total molecules in database ()	1200	1200
Total number of actives in database (Ta)	50	50
Total hits (Ht)	70	82
Active hits (Ha)	47	42
% yield of actives []	67.1%	51.2%
% ratio of actives []	94.0%	84.0%
Enrichment factor () []	16.1	12.3
False negatives [Ta-Ha]	3	8
False positives [Ht-Ha]	23	30
GH score	0.72	0.57