Ligand-Based and Docking-Based Virtual Screening of MDM2 Inhibitors as Potent Anticancer Agents

Table 4

In vitro antiproliferative activities of compounds AO-476/43250177, AG-690/37072075, AK-968/15254441, AO-022/43452814, and AF-399/25108021.

Comp.	Specs ID
		MCF7 (p53 +/+)	MCF7 (p53 -/-)	HCT116 (p53 +/+)	HCT116 (p53 -/-)
2	AO-476/43250177	>100	>100
5	AG-690/37072075
8	AK-968/15254441	>100	>100	>100	>100
10	AO-022/43452814
15	AF-399/25108021	>100	>100
Nutlin-3a	—