Modeling the Effect of Binding Kinetics in Spatial Drug Distribution in the Brain

Figure 3

Drug transport in brain capillaries and active transport across the BBB into the brain ECF (a). A cubical lattice (blue) represents a piece of 3-dimensional brain tissue. The cubical lattice is formed of the network of smaller cubic lattices (red). The arrows indicate the bidirectional bulk flow of the brain ECF (b).