Research Article

[Retracted] Breast Cancer Cells Metastasize to the Tissue-Engineered Premetastatic Niche by Using an Osteoid-Formed Polycaprolactone/Nanohydroxyapatite Scaffold

Figure 5

The expression level of CXCL12 in the BPMN supernatants increased gradually as the coculture time increased. There was no significant difference between the day 0 and day 0.5 groups among all types of breast cancer cells. Additionally, similar results were obtained in the day 5 and day 7 groups, reaching its highest point on day 7. Notably, during the period of days 0.5-5, the expression of CXCL12 in each BPMN was remarkably increased when compared to their ancestors (). Data are presented as the (). and . BPMNs: bony premetastatic niches.