Dissecting the Pathogenesis of Diabetic Retinopathy Based on the Biological ceRNA Network and Genome Variation Disturbance

Figure 7

The functional effect of different genomic variations. (a–c) Individuals with different SNP genotypes will gain or lose miRNA binding sites and further disturb a ceRNA relation. (d) Some of the experimentally verified miRNA targets of hsa-miR-4435 were DR-related genes. (e–g) The differential expression of MIR4435-2HG, EGR, and PPARG between DR and normal retina samples. (h) The positive coexpression between MIR4435-2HG and ERG. (i–l) The TFBS binding motifs of EGR and PPARG.

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