Identification of 5 Hub Genes Related to the Early Diagnosis, Tumour Stage, and Poor Outcomes of Hepatitis B Virus-Related Hepatocellular Carcinoma by Bioinformatics Analysis

Figure 8

Representative histological images from the Human Protein Atlas database (THPA, https://www.proteinatlas.org/). Normal liver tissue with staining for CDK1 was obtained from a female subject aged 32 years (patient ID: 1846; staining: not detected; intensity: negative; quantity: none; location: none; magnification: not available), and HCC tissue was obtained from a female patient aged 73 years (patient ID: 2279; staining: medium; intensity: strong; quantity: <25%; location: cytoplasmic/membranous nuclear; magnification: not available). Normal liver tissue with staining for CCNB2 was obtained from a male subject aged 55 years (patient ID: 2429; staining: not detected; intensity: negative; quantity: none; location: none; magnification: not available), and HCC tissue was obtained from a female patient aged 52 years (patient ID: 2399; staining: medium; intensity: moderate; quantity: 75%-25%; location: cytoplasmic/membranous; magnification: not available). Normal liver tissue with staining for CDC20 was obtained from a male subject aged 67 years (patient ID: 1720; staining: not detected; intensity: negative; quantity: none; location: none; magnification: not available), and HCC tissue was obtained from a male patient aged 57 years (patient ID: 1175; staining: medium; intensity: strong; quantity: <25%; location: cytoplasmic/membrane nuclear; magnification: not available). Normal liver tissue with staining for CCNB1 was obtained from a female subject aged 32 years (patient ID: 1846; staining: not detected; intensity: negative; quantity: none; location: none; magnification: not available), and HCC tissue was obtained from a female patient aged 65 years (patient ID: 937; staining: medium; intensity: strong; quantity: <25%; location: cytoplasmic/membranous; magnification: not available). Normal liver tissue with staining for CENPF was obtained from a female subject aged 32 years (patient ID: 1846; staining: not detected; intensity: negative; quantity: none; location: none; magnification: not available), and HCC tissue was obtained from a female patient aged 65 years (patient ID: 937; staining: medium; intensity: strong; quantity: <25%; location: cytoplasmic/membranous; magnification: not available). Normal liver tissue with staining for MAD2L1 was obtained from a male subject aged 55 years (patient ID: 2429; staining: not detected; intensity: negative; quantity: none; location: none; magnification: not available), and HCC tissue was obtained from a female patient aged 67 years (patient ID: 3334; staining: medium; intensity: moderate; quantity: >75%; location: cytoplasmic/membranous; magnification: not available). CDK1: cyclin-dependent kinase 1; CCNB2: cyclin B2; CDC20: cell division cycle 20; CCNB1: cyclin B1; NDC80: NDC80 kinetochore complex component; CENPF: centromere protein F; MAD2L1: mitotic arrest deficient 2 like 1; NUF2: NUF2 component of NDC80 kinetochore complex.