Circadian Clock Genes Are Correlated with Prognosis and Immune Cell Infiltration in Colon Adenocarcinoma

Table 1

Prognostic performance of core circadian genes in COAD based on TCGA cohort.

Genes	OS		DFS		DSS		PFS
	value	HR (95% CI)	value	HR (95% CI)	value	HR (95% CI)	value	HR (95% CI)
CLOCK	0.295	0.81 (0.55-1.20)	0.246	0.61 (0.26-1.41)	0.155	0.70 (0.42-1.15)	0.444	0.87 (0.61-1.24)
ARNTL	0.745	1.07 (0.72-1.58)	0.837	1.09 (0.48-2.47)	0.695	1.10 (0.67-1.80)	0.934	1.02 (0.71-1.45)
CRY1	0.566	0.89 (0.60-1.31)	0.057	0.42 (0.17-1.03)	0.481	0.84 (0.51-1.37)	0.101	0.74 (0.52-1.06)
CRY2	0.032	1.54 (1.04-2.30)	0.040	2.56 (1.04-6.29)	0.049	1.66 (1.00-2.74)	0.022	1.52 (1.06-2.18)
NR1D1	0.211	1.29 (0.87-1.91)	0.006	4.03 (1.50-10.87)	0.404	1.24 (0.75-2.03)	0.003	1.76 (1.22-2.54)
PER1	0.220	1.28 (0.86-1.89)	0.884	1.06 (0.46-2.45)	0.424	1.22 (0.75-2.00)	0.063	1.40 (0.98-2.01)
PER2	0.047	1.49 (1.00-2.21)	0.069	2.29 (0.94-5.59)	0.077	1.57 (0.95-2.58)	0.065	1.40 (0.98-2.00)
PER3	0.885	1.03 (0.70-1.52)	0.561	1.28 (0.56-2.90)	0.790	0.94 (0.57-1.53)	0.671	1.08 (0.76-1.54)
RORA	0.895	0.97 (0.66-1.44)	0.817	0.91 (0.40-2.06)	0.948	0.98 (0.60-1.61)	0.735	1.06 (0.75-1.52)