| | Family | Cancer development |
| | HSP27 | Response to heat shock and recovery of damaged proteins, regulation of cytoskeleton dynamics
Modulation of tumour initiation, progression, cancer stem cell programming, and metathesis by Hippo pathway
Regulation of cancer development, EMT, cell proliferation, migration, and invasion
Relation of poor prognosis and biomarker for cancer diagnosis |
| | HSP40 | Classified into DnaJB and DnaJC
Regulation of protein folding, refolding, translation, translocation, and degradation
Association with progression, growth, invasion, and metastasis in cancer
DNAJ transcriptome analysis—relation of lymphatic invasion, infiltrative growth type, lymph node metastasis, cell proliferation, and progression in cancer |
| | HSP60 | Localization in mitochondria, relation of quality control (mitochondrial function, proteostasis, and transport and folding of mitochondrial proteins
Function as a promoter and suppressor of cancer
Regulation of cell growth, differentiation, invasion, metastasis, and mitochondrial biogenesis in cancer |
| | HSP70 | Five important family (HSP27, HSP70B, HSC70, Mortalin, and GRP78)
Important roles in protein folding, homeostasis, and cell survival
Association with cancer development, progression, malignancy, recurrence, and poor prognosis
Regulation of cell proliferation, migration, invasion, apoptosis, and phenotype of cancer stem cells |
| | HSP90 | Relation to protein folding, stabilization, activation, and proteolytic degradation
Modulation of tumour growth, adhesion, invasion, metastasis, angiogenesis, and apoptosis
Association with cancer development, progression, and poor prognosis |
| | HSF1 | Master regulator of all heat shock responses
Modulation invasion, migration, and EMT of cancer
Regulation of tumour growth, overall survival, apoptosis, and metabolism in cancer
Association with cancer development, progression, and poor prognosis |
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