MMP1 Overexpression Promotes Cancer Progression and Associates with Poor Outcome in Head and Neck Carcinoma

Figure 6

The GO, KEGG, and GSEA analyses results for the differentially expressed genes between high-MMP1 and low-MMP1 groups. (a, c) GO (upper panel) and KEGG (low panel) analysis for the correlated genes in MMP1-high group. (b, d) GO (upper panel) and KEGG (low panel) analysis for the correlated genes in MMP1-low group. (e–h) Functional annotations of DEGs between two groups by GSEA analyses revealed high enrichment in several cancer-relevant categories including enriched in EMT pathway (e), epidermal cell differentiation (f), focal adhesion (g), and P53 signaling pathway (h). GSEA enrichment plots with normalized enrichment score (NES) and -values were shown.

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