MMP1 Overexpression Promotes Cancer Progression and Associates with Poor Outcome in Head and Neck Carcinoma

Table 2

Univariate and multivariate survival analyses (proportional hazards method) for patients with primary HNSCC.

Variable	Univariate survival analysis			Multivariate survival analysis
	Hazard ratio	95% CI	-value	Hazard ratio	95% CI	-value
Gender (male, female)	1.132	0.558-2.299	0.731	1.070	0.334-3.423	0.909
Smoking (no, yes)	1.095	0.504-2.378	0.819	1.389	0.469-4.108	0.553
Alcohol use (no, yes)	0.802	0.389-1.654	0.550	0.648	0.205-2.047	0.460
Age (≤60, >60)	1.192	0.561-2.535	0.648	1.588	0.730-3.452	0.243
Tumor size (T1-T2, T3-T4)	0.675	0.236-1.931	0.463	0.575	0.199-1.660	0.306
Pathological grade (I, II-III)	1.307	0.871-1.961	0.196	1.206	0.779-1.867	0.838
Cervical nodal metastasis (N0, N+)	1.402	0.628-3.133	0.410	1.816	0.483-6.832	0.377
Clinical stage (I-II, III-IV)	1.302	0.548-4.133	0.549	1.273	0.788-2.198	0.641
MMP1 expression (low, high)	3.306	1.163-7.928	0.023	3.410	1.281-9.082	0.014

indicate statistical significance with -values less than 0.05.