Research Article

Chelerythrine Chloride Inhibits Stemness of Melanoma Cancer Stem-Like Cells (CSCs) Potentially via Inducing Reactive Oxygen Species and Causing Mitochondria Dysfunction

Figure 5

CHE increased ROS level and ATP function, which were reversed by NAC. After CHE treatment, with or without the presence of NAC, a ROS scavenger, (a) cellular ROS level was measured by ROS-Glo staining and (b) mitochondrial ROS was measured by MitoSOX Red staining. vs mock group; # vs CHE group (). (c) Sphere formation capacity was observed with the addition of NAC or CHE after 96 h incubation.
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