Combination of the NRF2 Inhibitor and Autophagy Inhibitor Significantly Inhibited Tumorigenicity of Castration-Resistant Prostate Cancer

<div>NRF2 is upregulated in mCRPC samples compared to HSPC samples. (a) NRF2 was highly expressed in mCRPC samples compared to HSPC samples. (b) The protein levels of NRF2 in a TMA containing 84 neoadjuvant endocrine therapy (NHT) PCa samples, 54 neoadjuvant endocrine + neoadjuvant chemotherapy (NCHT) PCa samples, 281 untreated PCa samples, and 43 CRPC and 10 SCC samples were detected using IHC methods.</div>

Computational and Mathematical Methods in Medicine

fig4

Figure 4

Figure 4: Combination of the NRF2 Inhibitor and Autophagy Inhibitor Significantly Inhibited Tumorigenicity of Castration-Resistant Prostate Cancer 