A Framework to Predict the Molecular Classification and Prognosis of Breast Cancer Patients and Characterize the Landscape of Immune Cell Infiltration

Figure 4

Correlations between immune-cell infiltration (ICI) scores and tumor mutation burden (TMB). (a) Differences in TMB between high or low ICI score groups (Kruskal test, ). (b) Scatter plot of correlation between ICI scores and the mutational burden in the TCGA-BRCA cohort (Pearson’s correlation =0.133, ). (c) Stratified survival analysis of TCGA-BRCA patients stratified by both TMB and ICI scores (calculated by using PCA) using Kaplan Meier curves. The log-rank test showed that . (d) Waterfall plots of the top 25 significantly driver mutated genes in the high (left) or low (right) ICI score groups. Each column represents for individual patients, and the bar plot on top shows the TMB. GISTIC2.0-based copy number variant (CNV) analysis of (e) high or (f) low ICI score groups visualized by maftools.

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