Identification of the Key Genes Involved in the Tumorigenesis and Prognosis of Prostate Cancer

Figure 2

Construction of coexpression network and hub gene screening. (a) Analysis of the scale-free fit index () and the mean connectivity with different soft-thresholding powers. At , the mean connectivity close to zero was considered an appropriate soft threshold. When we choose eight as our power, . (b) WGCNA module depicting the gene trait correlation plot showing the clustering dendrograms of genes. The clustering was based on 471 samples of TCGA-PRAD RNA-seq data. The color intensity varies positively with PSA, Gleason score, and T, N, and M stages. (c) The WGCNA module trait correlation plot. Overview of the modules generated by the WCGNA and their relationship with module eigengenes and the clinical traits of PCa. Each row represents a module, and each column represents a trait attribute. The blue color represents a negative correlation, and the red represents a positive correlation. (d) The gene expression in the green module.

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